The Merck Manual is continually updating the online version. Updates of selected topics are posted about every two months. The following updated topics have recently been posted:

	Mineral Deficiency and Toxicity
	Tumors of the Head and Neck
	Cataract
	Optic Nerve Disorders
	Orbital Diseases
	Acne and Related Disorders
	Fungal Skin Infections
	Parasitic Skin Infections
	Hair Disorders
	Leukemias
	Lymphomas
	Overview of Cancer
	Porphyrias
	Immunodeficiency Disorders
	Allergic and Other Hypersensitivity Disorders
	Function and Dysfunction of the Cerebral Lobes
	Cystic Fibrosis
	Cold Injury
	Principles of Radiologic Imaging

1. Sammut SJ, Brackley PT, Duncan C, et al: Frostbite following use of a commercially available cryotherapy device for the removal of viral warts. Dermatology Online Journal Jun 15; 14(6):9, 2008.

2. Bruen KJ, Ballard JR, Morris SE, et al: Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy. Archives of Surgery Jun; 142(6):546–551; discussion 551–553, 2007.

3. Folio LR, Arkin K, and Butler WP: Frostbite in a mountain climber treated with hyperbaric oxygen: case report. Military Medicine May; 172(5):560–563, 2007.

4. Jurkovich GJ: Environmental cold-induced injury. Surgical Clinics of North America Feb; 87(1):247–267, viii, 2007.

5. Yazawa H, Saga K, Omori F, et al: The chilblain-like eruption as a diagnostic clue to the blast crisis of chronic myelocytic leukemia. Journal of the American Academy of Dermatology Feb; 50(2 Suppl):S42–S44, 2004.

Weekly podcasts provide reviews of patient symptoms based on topics of the same title from The Merck Manual of Patient Symptoms. Click here to listen.

Recently released podcasts

• Chest Pain
• Hemoptysis
• Hiccups

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Each issue features a MinIQuiz relating to the recently updated topics. The MinIQuiz for this issue covers Cold Injuries, Acne and Related Disorders, Hair Disorders, and Optic Nerve Disorders. Correctly answer the MinIQuiz questions (you can use The Merck Manual Online) to be entered in a drawing to win a print or a PDA download version of The Merck Manual.
(Click here for MinIQuiz entry rules.)

Symptoms of frostbite can include all of the following except:

	Blisters
	Autoamputation
	Soft, red, warm, and numb extremities
	Gangrene

Take the quiz!

Last issue’s MinIQuiz focused on Neck and Back Pain, Anemias Caused by Deficient Erythropoiesis, Somatoform and Factitious Disorders, and Thyroid Disorders. Our winner is Dr. Elyse Michelson, an internist in a multi-specialty practice in Reistertown, Maryland.

View last issue's MinIQuiz answers.